Letteratura scientifica

Abstract

Synopsis: An implant-supported restoration of the maxillary anterior segment that is biologically, functionally, and esthetically acceptable following traumatic injuries in the maxillary anterior segment is always complex. Healing of the tissues is always difficult to control and the development of new techniques and materials to improve these treatments is still necessary.

The use of platelet concentrates is an interesting approach. The objective of this technique is to gather platelet growth factors and to inject them on a surgical site to stimulate the healing process. Leukocyte and platelet-rich fibrin (L-PRF™) allows for the preparation of strong fibrin membranes that are enriched with cells (activated platelets, leukocytes, circulating cells) and platelet growth factors.

This autologous healing biomaterial is free of additives such as anticoagulants during blood harvesting or chemicals for activation. In addition, it is simple, inexpensive, and quick to prepare (15 minutes for all steps). The technique that is presented is specifically adapted to the practical needs in daily implant dentistry.

This case letter documents the use of L-PRF™ during the replacement of a fractured central incisor with an immediate post-extraction implant and crown placement. As a strong solid fibrin membrane, L-PRF™ is seen to be particularly easy to use in implant dentistry and periodontology. In addition, it offers a protective effect (both mechanical and biological) to the grafted area.

The Use of Leukocyte- and Platelet-Rich Fibrin During Immediate Postextractive Implantation and Loading for the Esthetic Replacement of a Fractured Maxillary

Central Incisor

Del Corso M, Mazor Z, Rutkowski J L,

Dohan Ehrenfest D M.

J Oral Implantol 2012; 2012 Apr; 38(2):181-187. PubMed PMID: 22568469.

Regenerative

Medicine: 11

The PACT (Platelet & Advanced Cell Therapies) Forum: fostering translational research, transdisciplinarity and international collaboration in tissue engineering and regenerative medicine

Gilberto Sammartino, Marco Del Corso, Lidia M. Wisniewska, Tomasz Bielecki, Isabel Andia, Nelson R. Pinto, Chang-Qing Zhang, De-Rong Zou, and David M. Dohan Ehrenfest.

Analysis of the Leukocytes in peripheral blood and Leukocyte- and Platelet-Rich Plasma (L-PRP) in rats: A flow cytometry study.

Agata Cieslik-Bielecka, Piotr Paczek, Lukasz Sedek, Aleksandra Szantyr, Rafal Skoronski, Hom-Lay Wang, and David M. Dohan Ehrenfest.

The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors and fibrin architecture of a Leukocyte- and Platelet-Rich Fibrin (L-PRF™) clot and membrane. Part 1: evaluation of the vibration shocks of 4 models of table centrifuges for L-PRF™.

David M. Dohan Ehrenfest, Byung-Soo Kang, Marco Del Corso, Mauricio Nally, Marc Quirynen, Hom-Lay Wang, and Nelson R. Pinto.

The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors and fibrin architecture of a Leukocyte- and Platelet-Rich Fibrin (L-PRF™) clot and membrane. Part 2: macroscopic, photonic microscopy and Scanning Electron Microscopy analysis of 4 kinds of L-PRF™ clots and membranes.

Nelson R. Pinto, Andrea Pereda, Paula Jiménez, Marco Del Corso, Byung-Soo Kang, Hom-Lay Wang, Marc Quirynen, and David M. Dohan Ehrenfest.

The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors and fibrin architecture of a Leukocyte- and Platelet-Rich Fibrin (L-PRF™) clot and membrane. Part 3: comparison of the growth factors content and slow release between the original L-PRF™ and the modified A-PRF (Advanced Platelet-Rich Fibrin) membranes.

David M. Dohan Ehrenfest, Marco Del Corso, Byung-Soo Kang, Nicole Lanata, Marc Quirynen, Hom-Lay Wang, and Nelson R. Pinto.

Immediate implantation and peri-implant Natural Bone Regeneration (NBR) in the severely resorbed posterior mandible using Leukocyte- and Platelet-Rich Fibrin (L-PRF™): a

4-year follow-up

Marco Del Corso and David M. Dohan Ehrenfest

Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF™)

David M. Dohan Ehrenfest, Lars Rasmusson and Tomas Albrektsson Department of Biomaterials, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Sweden

Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering

Volker Gassling Timothy Douglas Patrick H. Warnke Yahya Ac¸il Jo¨rg Wiltfang Stephan T. Becker

The concept of Screw-Guided Bone Regeneration (S-GBR). Part 3: Fast Screw-Guided Bone Regeneration (FS-GBR) in the severely resorbed preimplant posterior mandible using allograft and Leukocyte- and Platelet-Rich Fibrin (L-PRF™):

a 4-year follow-up

Roland Toeroek and David M. Dohan Ehrenfest

Simultaneous Sinus-Lift and Implantation Using Microthreaded Implants and Leukocyte- and Platelet-Rich Fibrin as Sole Grafting

Material: A Six-Year Experience

Simonpieri, Alain DDS*; Choukroun, Joseph MD†; Corso, Marco Del DDS‡; Sammartino, Gilberto MD, PhD§; Ehrenfest, David M. Dohan DDS, MS, PhD

The Use of Leukocyte- and Platelet-Rich Fibrin During Immediate Postextractive Implantation and Loading for the Esthetic Replacement of a Fractured Maxillary Central Incisor

Del Corso M, Mazor Z, Rutkowski J L, Dohan Ehrenfest D M.

Nanometer-scale features onmicrometer-scale surface texturing: A bone histological, gene expression, and nano mechanical study

Paulo G. Coelho, Tadahiro Takayama, Daniel Yoo, Ryo Jimbo, Sanjay Karunagaran, Nick Tovar, Malvin N. Janal, Seiichi Yamano.

Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 1: description of the Implant Surface Identification Standard (ISIS) codification system.

David M. Dohan Ehrenfest, Marco Del Corso, Byung-Soo Kang, Philippe Leclercq, Ziv Mazor, Robert A. Horowitz, Philippe Russe, Hee-Kyun Oh, De-Rong Zou, Jamil Awad Shibli, Hom-Lay Wang, Jean-Pierre Bernard, and Gilberto Sammartino.

Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 2: anodized and Titanium Plasma-Sprayed (TPS) surfaces (Group 1, metallurgy modification).

Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 3: sand-blasted/acid-etched (SLA type) and related surfaces (Group 2A, main subtractive process).

Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 4: Resorbable Blasting Media (RBM), Dual Acid-Etched (DAE), Subtractive Impregnated Micro/Nanotextured (SIMN) and related surfaces (Group 2B, other subtractive process).

Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 5: chemically coated surfaces (Group 3, coating) and implant collar surfaces (Group 4, collar).

Fractal patterns applied to implant surface: definitions and perspectives

David Marcel Dohan Ehrenfest, DDS, MS, PhD1 University of Gothenburg, Department of Biomaterials, University of Gothenburg

Identification card and codification of the chemical and morphological characteristics of 14 dental implant surfaces.

David Marcel Dohan Ehrenfest, DDS, MS, PhD1, Lydia Vazquez, Yeong-Joon Park, Gilberto Sammartino,

and Jean-Pierre Bernard Chonnam National University School of Dentistry, LoB5 unit, School of Dentistry, Gwangju, South Korea

Histomorphometric Evaluation of Bioceramic Molecular Impregnated and Dual Acid Etched Implant Surfaces in the Human Posterior Maxilla

Jamil Awad Shibli, DDS, MS, PhD; Sauro Grassi, DDS, MS; Adriano Piattelli, MD, DDS; Gabriele E. Pecora, MD, DDS; Daniel S. Ferrari, DDS, MS; Tatiana Onuma, DDS; Susana d'Avila, DDS, MS, PhD; Paulo G. Coelho, DDS, PhD; Raquel Barros, DDS, MS; Giovanna Iezzi, DDS, PhD

Comparative Analysis of Early Bone Bonding Using Various Surface Treatments

R.J. Miller, P. Coelho, C. Marin, R. Granato, M. Suzuki, J. Gil Delray Beach, FL.

Biomechanical Testing of Microblasted, Acid-Etched/Microblasted Surfaces,Anodized, and Discrete Crystalline Deposition in the Canine Radius Model.

R. Granato, C. Marin, M. Suzuki, E. Bonfante, P.G. Coelho New York, NY.

Physico/Chemical Characterization and Biomechanical Evaluation of Three Different Grit-Blasting and Acid-Etching Surface Treatments. An Experimental Study in Dogs.

G.S. Bernardes, R.Granato, M. Suzuki, J.N. Gil, C. Marin, P.G. Coelho New York, NY

The Effect of Implant Surface and Macrodesign on Initial Stability. A Study in Dogs.

R.J. Miller, C. Marin, R. Granato, J.N. Gil, M. Suzuki, P.G. Coelho New York, NY.

Human Osteoblast growth on a Novel Implant Surface Vs a classic Blasted and Acid Etched Surface.

V. Bucci-Sabattini, C. Cassinelli, M. Morra Magenta, Italy.

Removal Torque and Histomorphometric Evaluation of Bioceramic

Grit-Blasted/Acid-Etched and Dual Acid-Etched Implant Surfaces: An Experimental Study in Dogs

Charles Marin*, Rodrigo Granato*, Marcelo Suzuki†, Jose N. Gil*, Adriano Piattelli‡, and Paulo G. Coelho§

Classification of osseointegrated implant surfaces: materials, chemistry and topography

David M. Dohan Ehrenfest1, Paulo G. Coelho2, Byung-Soo Kang1, Young-Taeg Sul1 and Tomas Albrektsson1

Basic Research Methods and Current Trends of Dental Implant Surfaces

Paulo G. Coelho1, Jose´ M. Granjeiro2, George E. Romanos3, Marcelo Suzuki4, Nelson R. F. Silva1, Giuseppe Cardaropoli1, Van P. Thompson1, Jack E. Lemons5

Surface treatment at the cervical region and its effect on bone maintenance after immediate implantation: An experimental study in dogs.

Paulo G. Coelho, DDS, MS, BS, MSMtE, PhD,a Charles Marin, DDS, MS,b Rodrigo Granato, DDS, MS,b Estevam A. Bonfante, DDS, MS, PhD,c Cirilo P. Lima, DVM, PhD,d and Marcelo Suzuki, DDS,e New York, New York; Florianopolis, Santa Catarina; Bauru, São Paulo; Uberlândia, Minas Gerais; and Boston, Massachusetts

Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales

Paulo G. Coelhoa, Ryo Jimbod, Nick Tovar, Estevam A. Bonfantee

Immediate Provisionalization of a Maxillary Lateral Incisor With a

Dental Mini-Implant: Surgical and Prosthetic Rationale

Kotaro Oyama, DDS, MS* • Joseph Y.K. Kan, DDS, MS† • Kitichai Rungcharassaeng, DDS, MS±

In vitro evaluation of the implant abutment connection sealing capability of different implant systems

P. G. Coelho*, P. Sudack*, M. Suzuki†, K. S. Kurtz‡, G. E. Romanos§ & N. R. F. A. Silva*

Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales

Paulo G. Coelhoa, Ryo Jimbod, Nick Tovar, Estevam A. Bonfantee

The effect of implant design on insertion torque and immediate micromotion

Amilcar C. Freitas Jr, Estevam A. Bonfante, Gabriela Giro, Malvin N. Janal, Paulo G. Coelho

Laboratory Torque Testing, Histomorphometric and Biomechanical Testing or Self-Tapping Implant Thread Designs.

S. Lin, R. Granato, C. Marin, M. Suzuki, E. Bonefante, G. Giro, P.G. Coelho New York, NY.

The impact of a modified cutting flute implant design on osseointegration

R. Jimbo, N. Tovar, C. Marin, H. S. Teixeira, R. B. Anchieta, L. M. Silveira, M. N. Janal, J. A. Shibli, P. G. Coelho:

The 'mini'-implant has arrived.

Christensen Gj

Mini dental implants for long-term fixed and removable prosthetics: a retrospective analysis of 2514 implants placed over a five-year period.

Shatkin TE, Shatkin S, Oppenheimer BD, Oppenheimer AJ.

Mini Dental Implants: A Retrospective Analysis of 5640 Implants Placed Over a 12-Year Period

Todd E. Shatkin, Chritopher A. Petrotto

ISurface Treatment of Small Diameter Implants and the Effect on Osseointegration and Crestal Bone Retention

Bruno Lemay, DMD,

Robert J. Miller, MA, DDS

Narrow-implant–retained overdenture in an atrophic mandibular ridge: a case report with 6-year follow-up

Carlos Roberto Garcia Araujo, DDS, Paulo Antonio Martins-Junior, DDS, MSc, PhD, Roberto Carlos de Araujo, DDS, MSc, Marcos Augusto de Sa, MSc, PhD, Thomaz Wassall, DDS, PhD, Anderson Jose Ferreira, DDS, MSc, PhD

The Clinical Outcomes of Immediate Versus Delayed Restoration Procedures on Immediate Implants: A Comparative Cohort Study for Single-Tooth Replacement

Antonio Barone, DDS, PhD, MSc*†; Paolo Toti, BSc, DDS*†; Alessandro Quaranta, DDS, PhD‡, Giacomo Derchi, DDS*†; Ugo Covani, MD, DDS*†

New Frontiers in

Immediate Loading

Vincenzo Bucci Sabattini

Mini Dental Implants: A Retrospective Analysis of 5640 Implants Placed Over a 12-Year Period.

Shatkin Todd E, Petrotto Christopher A.

Insertion torque in different bone models with different screw pitch: an in vitro study.

Authors: Orlando B, Barone A, Giorno TM, Giacomelli L, Tonelli P, Covani U

Biomechanical Evaluation of Endosseous Implants at Early Implantation Times:

A Study in Dogs

Paulo G. Coelho, DDS, PhD*, Rodrigo Granato, DDS, MSc†, Charles Marin, DDS, MSc‡, Estevam A. Bonfante, DDS, MSc, PhD§, Jose N.O. Freire, DDS, PhD, Malvin N. Janal, PhD, Jose N. Gil, DDS, MSc, PhD#, and Marcelo Suzuki, DDS**

Early Bone Healing around Different Implant Bulk Designs and Surgical Techniques: A Study in Dogs

Paulo G. Coelho, DDS, PhD; Marcelo Suzuki, DDS; Marcia V.M. Guimaraes, DDS, MS, DSc; Charles Marin, DDS, MS; Rodrigo Granato, DDS, MS; Jose N. Gil, DDS, MS, DSc; Robert J. Miller, DMD

Changes in Bone Levels Around Mini-Implants in Edentulous Arches

Torsten Mundt, DMD, Dr Med Dent / Christian Schwahn, Dr Rer Med/ Reiner Biffar, DMD, Dr Med Dent/Friedhelm Heinemann, DMD, Dr Med Dent

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Rigenerazione Guidata Naturale | L-PRF™

Superficie Implantare | Ossean®

Connessione (Meccanica) Protesica | InDex™

Architettura Implantare | Blossom®

Impianti di diametro ridotto | MDL® and MILO®

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